Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)-
PFI-1
CAS: 1403764-72-6
Molecular Formula: C16H17N3O4S
Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)- - Names and Identifiers
Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)- - Physico-chemical Properties
| Molecular Formula | C16H17N3O4S |
| Molar Mass | 347.39 |
| Solubility | DMSO: ≥10mg/mL |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | Sealed in dry,2-8°C |
| MDL | MFCD22580416 |
| Use | PFI-1 |
| In vitro study | PFI-1 binds to the cAMP response binding element binding protein with a K D of 49 μm. PFI-1 inhibition of IL-6 production from LPS-stimulated human blood mononuclear cells, the EC50 was 1.89 μm. PFI-1 action on T4302 CD133 PFI-1 inhibit the proliferation of three NET cell lines (pancreatic NET-derived Bon-1, and lung NET-derived H727 and H720). |
| In vivo study | PFI-1 was administered intravenously to rats at a dose of 1 mg/kg with a volume of distribution of 1 L/kg and a plasma clearance of 18/mL • min. |
Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)- - Risk and Safety
| WGK Germany | 3 |
Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.879 ml | 14.393 ml | 28.786 ml |
| 5 mM | 0.576 ml | 2.879 ml | 5.757 ml |
| 10 mM | 0.288 ml | 1.439 ml | 2.879 ml |
| 5 mM | 0.058 ml | 0.288 ml | 0.576 ml |
Last Update：2024-01-02 23:10:35
Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)- - Reference Information
| biological activity | PFI-1 (PF-6405761) is a highly selective BET (Bromodomain-containing protein) inhibitor, the IC50 in the cell-free assay was 0.22 μm and 98 nM for BRD4 and BRD2, respectively. |
| Target | Value |
| BRD2 (Cell-free assay) | 98 nM |
| BRD4 (Cell-free assay) | 0.22 μM |
Last Update：2024-04-09 02:00:14
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Spot supply
Product Name: PFI-1 Visit Supplier Webpage Request for quotationCAS: 1403764-72-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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